πŸš€ SIRT6 Longevity Platform: Development Strategy πŸš€

DNA Design Challenge_Strategic Implementation Matrix.png

HTGAA25: DNA Design Challenge Submission

πŸš€ SIRT6 Longevity Platform: Accelerated Development Strategy πŸš€


Introduction

Sirtuin-6 (SIRT6) is a NAD⁺-dependent enzyme linked to genomic stability and aging. Studies suggest that SIRT6 overexpression or activation enhances DNA repair and metabolic regulation, conferring anti-aging effects [Nature]. These properties make SIRT6 a prime longevity target for a fast-tracked R&D pipeline. Below is an accelerated development framework that integrates:

βœ… Optimized DNA design for maximal SIRT6 expression

βœ… Diverse expression systems (E. coli, yeast, mammalian, cell-free)

βœ… CRISPR activation for endogenous SIRT6 upregulation

βœ… High-throughput protein production & purification

βœ… Regulatory and market path analysis

βœ… Bioelectric module for future integration

By running parallel experimental workflows and leveraging automation + AI-driven insights, we aim to compress R&D timelines for a viable SIRT6-based intervention.


Strategic Implementation Matrix

πŸ”ΉΒ Infographic Visualization: SIRT6 Longevity Platform Overview